Atopic Dermatitis Linked to Celiac Disease

eczema_atopic_dermatitis-celiac-diseaseAutoimmune disease comorbidity among adults with atopic dermatitis is common, according to a study recently published the British Journal of Dermatology.

  • HealthDay News, 1

What is atopic dermatitis? 2

“Atopic dermatitis (AD) is the most common type of eczema, affecting more than 9.6 million children and about 16.5 million adults in the United States. It’s a chronic condition that can come and go for years or throughout life, and can overlap with other types of eczema.”

“In people with AD, for complex reasons science hasn’t fully sorted out, the immune system becomes disordered and overactive. This triggers inflammation that damages the skin barrier, leaving it dry and prone to itching and rashes that may appear purple, brown or grayish hue in darker skin tones and red in lighter skin tones.”


Lina U. Ivert, from the Karolinska Institutet in Stockholm, and colleagues used Swedish national health care registers (1968 to 2016) to examine the association between atopic dermatitis and autoimmune diseases. The analysis included 104,832 cases of atopic dermatitis and 1,022,435 age- and sex-matched healthy controls.

  • The researchers found that atopic dermatitis was significantly associated with one or more autoimmune diseases compared with controls (adjusted odds ratio [aOR], 1.97).
  • This association was significantly stronger in the presence of multiple autoimmune diseases versus just one.
  • The strongest associations were seen for autoimmune disorders involving the skin (aOR, 3.10), the gastrointestinal tract (aOR, 1.75), or connective tissue (aOR, 1.50).
  • Men with atopic dermatitis had a stronger association with rheumatoid arthritis and celiac disease versus women with atopic dermatitis. Findings remained consistent after adjusting for smoking and parental autoimmune disease.

“Greater awareness, screening, and monitoring of autoimmune comorbidities may relieve the disease burden in patients with atopic dermatitis and may give deeper insight into its pathogenesis,” Ivert said in a statement.