Celiac Disease vs Non-Celiac Gluten Sensitivity vs Wheat Allergy

Symptoms are similar, but the conditions are very different. A terrific overview by Dr. Rubio Tapia allows us to tease them apart.

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If you feel unwell (or horrible) after eating wheat or gluten, you’re not alone. Three different conditions — celiac disease, non-celiac gluten sensitivity (NCGS) and wheat allergy — can cause problems when you eat these foods. And together, these three conditions affect millions of people in the U.S and around the world.

So, what’s the difference between celiac disease, NCGS and wheat allergy — and what should you do if you think you have one of these conditions? Gastroenterologist Alberto Rubio Tapia, MD, clears up the confusion.

Quick Definitions:

Celiac disease: It’s an autoimmune disease. Eating gluten damages your small intestine.
Wheat allergy: Your immune system overreacts to wheat. It can be life-threatening.
Non-celiac gluten sensitivity (NCGS)/gluten intolerance/gluten sensitivity: You test negative for celiac but react badly to gluten.

Article Outline

Celiac disease vs. NCGS (gluten intolerance)
1. NCGS (gluten intolerance) symptoms and celiac disease
2. NCGS (gluten intolerance) — is it really about gluten?
Is a wheat allergy related to NCGS (gluten intolerance) and celiac disease?
Wheat allergy vs. celiac disease
Wheat allergy vs. NCGS (gluten intolerance)
How to know which condition you have?
1. Diagnosing celiac disease
2. Diagnosing non-celiac gluten sensitivity
3. Diagnosing wheat allergy
General Questions
1. Can NCGS (gluten sensitivity) become celiac?
2. Is a gluten-free diet healthier?
3. If you go gluten-free without a medical reason, you risk …
4. When to see your doctor
5. Life without wheat or gluten

1. Celiac disease vs. NCGS (gluten intolerance)

Celiac disease and NCGS, also called gluten intolerance or gluten sensitivity, seem similar on the surface. Both conditions can cause uncomfortable symptoms after you eat gluten. But that’s where the similarities end, says Dr. Rubio Tapia.

“Celiac disease is an immune system disorder that damages your small intestine when you eat even a tiny amount of gluten. Celiac also runs in families,” explains Dr. Rubio Tapia. “NCGS is a digestive disorder, not an immune system problem. NCGS doesn’t damage your intestine, and it doesn’t run in families.”

1. NCGS (gluten intolerance) symptoms and celiac disease

If they’re so different, why do people confuse celiac disease and NCGS (gluten intolerance)? Because they have two things in common:

NCGS and celiac disease have nearly identical symptoms.
Your symptoms get better when you cut gluten from your diet.

So, if you have celiac or NCGS, you might notice that eating gluten causes:

Bloating, gas and constipation.
Brain fog, fatigue and headaches.
Depression.
Diarrhea and nausea.
Joint pain.

Despite their overlap in symptoms, how bad you feel isn’t an indicator of what’s ailing you. “Some people with celiac have no symptoms at all,” notes Dr. Rubio Tapia. “And a person with NCGS could have very severe symptoms after eating gluten. We have to do tests to find out what’s going on.”

2. NCGS (gluten intolerance) — is it really about gluten?

Things get more complicated with NCGS (gluten intolerance). Recent research suggests that NCGS may not be a reaction to gluten at all. What we call “NCGS” could be a reaction to something else in the most common grains we eat.

“We know that the symptoms of NCGS are very real,” says Dr. Rubio Tapia. “People with this condition are sensitive to something in certain grains, but it might not be gluten. Studies haven’t been able to pinpoint gluten as the offender in people with NCGS.”

Dr. Rubio Tapia says some studies are looking at amylase/trypsin-inhibitors (ATIs) as a trigger for NCGS. Like gluten, ATIs are proteins in wheat, barley and rye. And they might be the reason people feel like gluten is the root of their health problems.

“ATIs could be causing symptoms in people with NCGS, but we need more studies to find out,” says Dr. Rubio Tapia. “We know that people with NCGS get relief when they stop eating gluten. But when you go gluten-free, you’re also going ATI-free because these two proteins are in the same foods.”

2. Is a wheat allergy related to NCGS (gluten intolerance) and celiac disease?

“A mild wheat allergy could look like celiac or NCGS,” says Dr. Rubio Tapia. “But if you have a wheat allergy, you need to avoid wheat completely because allergic reactions can be dangerous. It’s important to get a diagnosis — don’t just assume you have gluten intolerance.”

Allergies happen when your immune system attacks something that’s usually harmless. If you have a wheat allergy, you’ll have a reaction anytime you eat something with wheat — even a tiny amount. People with severe allergies react to inhaling or smelling wheat, even if they don’t eat it. (This type of reaction won’t happen if you have NCGS or celiac disease.)

If you have a wheat allergy and eat something with wheat in it, you may experience:

Anaphylaxis, a severe, life-threatening reaction that causes swelling and trouble breathing.
Headache.
Hives or skin rash.
Nausea and vomiting.
Runny nose, congestion or sneezing.
Wheezing or asthma attack.

3. Wheat allergy vs. celiac disease

Wheat allergy and celiac disease have a few things in common. They both involve an immune system reaction. And both can run in families. You have a higher risk of having a wheat allergy if you have a close family member with allergies, asthma or eczema.

In some cases, the symptoms can look similar, too. And you have to completely avoid the offending food, whether it’s wheat or gluten.

There is a key difference, though. Almost two-thirds of people with a wheat allergy outgrow it by age 12, according to the American College of Allergy, Asthma & Immunology. People with celiac disease don’t outgrow it.

4. Wheat allergy vs. NCGS (gluten intolerance)

Wheat allergy and NCGS can have some similar symptoms, such as nausea. But they’re not related — not even distant cousins.

“NCGS can cause painful symptoms, but the condition has nothing to do with allergies,” states Dr. Rubio Tapia. “Allergic reactions can be life-threatening, and NCGS isn’t. But NCGS can affect your quality of life.”

5. How to know which condition you have?

There are plenty of gluten-free foods available in stores today. Should you just stop eating gluten and not worry about which condition you have? No. If you go gluten-free before getting medical tests, your results won’t be accurate.

“Tests for celiac disease only work if you’ve been eating gluten,” explains Dr. Rubio Tapia. “That’s why you should not self-diagnose and just go gluten-free. See your provider first and have tests done before eliminating any foods from your diet.”

1. Diagnosing celiac disease

If your provider thinks you could have celiac disease, they may recommend:

Antibody test: You might need a blood test to check for tissue transglutaminase IgA antibodies (tTG-IgA). Your body makes these antibodies after you eat gluten if you have celiac disease. If you have a parent or sibling with celiac, your provider may recommend antibody tests, even if you don’t have celiac disease symptoms.
Genetic test: A blood test can check for genes related to celiac disease. A negative genetic test result usually rules out celiac disease. But a positive result means you need further testing to confirm the diagnosis.
Biopsy: If blood tests show that you have celiac antibodies, your provider may take a biopsy (sample) of the inside of your small intestine. They send this sample to a lab, where experts look for signs of damage caused by celiac disease.

It’s normal to feel a little shocked or even upset if you’re diagnosed with celiac disease. There are resources available to help you follow a gluten-free lifestyle and, with guidance from your provider, you can learn how to find hidden gluten and which foods are best for you.

2. Diagnosing non-celiac gluten sensitivity

Usually, a diagnosis of NCGS requires two things:

Negative blood tests for celiac disease.
Feeling better when you stop eating gluten.

“There’s no blood test that can confirm NCGS,” says Dr. Rubio Tapia. “So, we diagnose NCGS when we rule out celiac disease and allergy. It’s important to get tested because celiac disease can cause long-term damage to your intestines. We need to know if you have celiac, so you can strictly avoid gluten and stay healthy.”

3. Diagnosing wheat allergy

Food allergies are your immune system’s reaction to certain proteins. People can be allergic to the proteins in wheat, barley or rye — or many other foods. If your provider thinks you could have a wheat or grain allergy, they may do:

Blood tests: People with a wheat allergy have immunoglobulin E antibodies (IgE) to wheat protein.
Skin-prick test: Your provider uses thin, short needles to place a small amount of wheat protein just under your skin. If your skin reacts with redness, swelling or hives, you may have a wheat allergy.
Oral food challenge: While a medical team watches you closely, you eat a small amount of wheat. The team is prepared to give you epinephrine, which stops anaphylaxis. However, Dr. Rubio Tapia notes that this test is rarely needed.

If you or your child has a wheat allergy, avoiding all wheat is important. Your provider may recommend seeing a nutritionist to talk about diet changes that will keep you or your child safe.

6. General Questions

1. Can NCGS (gluten sensitivity) become celiac?

If you learn you have NCGS, you might wonder if celiac disease is waiting in the wings. But there’s no evidence to support that the two are related.

“People with NCGS do not have a higher risk of celiac disease,” says Dr. Rubio Tapia. “It’s natural to worry about this because the two seem like similar conditions. But they’re not connected at all.”

2. Is a gluten-free diet healthier?

Some athletes and celebrities sing the praises of gluten-free diets. But can you boost your health by skipping gluten?

“There’s no benefit to a gluten-free diet unless you have a medical condition that requires it,” states Dr. Rubio Tapia. “Avoiding gluten when you don’t have an allergy, celiac disease or NCGS can harm your health. And there’s no evidence that eating gluten will trigger celiac disease in people without a family history of it.”

3. If you go gluten-free without a medical reason, you risk:

Inaccurate blood tests for celiac disease and NCGS if you need testing later.
Lower fiber intake, which is necessary for healthy digestion.
Vitamin or mineral deficiencies because gluten-free products aren’t required to be enriched like gluten products are. Gluten-containing grains are enriched with essential nutrients like B vitamins and iron.

4. When to see your doctor

A parent or sibling with celiac disease, as your provider may want to test you for celiac, even if you don’t have symptoms.
Symptoms of celiac disease, NCGS or a wheat allergy when you eat gluten.
Other health conditions, like Type 1 diabetes or autoimmune conditions, which make you more likely to have or develop celiac disease.

5. Life without wheat or gluten

It can be hard to live with a condition that strictly forbids gluten. You may have to seek out foods that won’t make you sick at restaurants, parties and family gatherings. Additionally, many people don’t understand these conditions and dismiss them as “not that serious.”

Reach out to your provider if you find that living with celiac disease, NCGS or a wheat allergy is affecting your physical or mental health. Your provider is your healthcare partner, here to help you feel your best. They can guide you through ways to manage your condition and find support groups, where you can connect with others who understand.

You can live a full, active — and delicious — life, even without gluten.

¹ https://health.clevelandclinic.org/gluten-sensitivity-celiac-disease-wheat-allergy-differences